|
KMID : 1188320120060030321
|
|
Gut and Liver
2012 Volume.6 No. 3 p.321 ~ p.327
|
|
|
The COX-2-1195AA Genotype Is Associated with Diffuse-Type Gastric Cancer in Korea
|
|
Shin Woon-Geon
Kim Ha-Jung
Cho Sung-Jin
Kim Hyoung-Su
Kim Kyung-Ho
Jang Myoung-Kuk
Lee Jin-Heon
Kim Hak-Yang
|
|
|
Abstract
|
|
|
Background/Aims:The potential role of the cyclooxygenase (COX)-2 polymorphism has been reported in relation to the risk of gastrointestinal tract malignancies. Therefore, we investigated whether COX-2 polymorphisms are associated with the risk of gastric cancer (GC) in Korea, one of the areas with a high prevalence of this condition.
Methods:We evaluated the genotypic frequencies of COX-2-765 and -1195 in 100 peptic ulcer patients, 100 GC patients, and 100 healthy controls. The polymorphisms of the COX-2-765 and -1195 genes were analyzed by polymerase chain reaction and restriction fragment length polymorphisms.
Results:The frequencies of the COX-2-1195 GG, GA, and AA genotype were 20%, 60%, and 20% in intestinal-type GC and 8%, 48%, and 44% in diffuse-type GC, respectively (p=0.021). There were no significant differences in the frequency of COX-2-765 genotypes between intestinal-type GC and diffuse-type GC (p=0.603). Age- and sex-adjusted logistic regression analysis showed that the COX-2-1195 AA genotype was the independent risk factor of diffuse-type GC compared with the COX-2-1195 GG genotype (p=0.041; odds ratio, 6.22; 95% confidence interval, 1.077 to 35.870).
Conclusions:The COX-2-1195 AA genotype may render subjects more susceptible to diffuse-type GC.
|
|
|
KEYWORD
|
|
|
Stomach neoplasms, Diffuse type, COX-2, Polymorphism
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|
|